Mitral Valve Insufficiency: Etiology, Pathophysiology, and Clinical Manifestations








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Mitral valve insufficiency is a condition where the mitral valve does not close properly during the systolic phase, leading to regurgitation of blood from the left atrium to the left ventricle. This condition can be caused by various factors including rheumatic heart disease, atherosclerosis, and infectious endocarditis. The pathophysiology involves the mitral valve apparatus and the hemodynamic changes in the heart. Clinically, mitral valve insufficiency can present with symptoms such as shortness of breath, fatigue, and palpitations. The diagnosis is typically made using various imaging techniques including echocardiography, electrocardiography, and chest X-rays.