The collecting ducts (CDs) and urine adjustment process








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The collecting ducts (CDs) play a crucial role in the final adjustment of urine volume and osmolality. Under normal conditions, the volume of urine in an adult male is approximately 1-1.5 L/day, with an osmolality of 500-600 mOsm/L. The CDs receive hypotonic fluid from the DCTs and are split into cortical collecting ducts (CCD) and medullary collecting ducts (MCD). Key functions include reabsorption of Na+ (facilitated by aldosterone in CCDs), water (dependent on ADH presence, termed facultative water reabsorption), and urea. This process ensures proper urine concentration and body fluid balance.