The loops of Henle and renal countercurrent mechanism








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The article delves into the function of the loops of Henle (LH) as a countercurrent system crucial for urine concentration in the kidney. It outlines how the LH, along with the vasa recta and medullary collecting ducts, contributes to establishing and maintaining hyperosmolality in the renal medullary interstitium (MI). The LH operates as a countercurrent multiplier system, creating an osmotic gradient, while the vasa recta functions as a passive countercurrent exchanger. The medullary collecting ducts ensure osmotic equilibrium between tubular fluid and the MI. This detailed explanation highlights the complex mechanisms underlying renal physiology.